| 释义 |
octopamine Biochem.|ɒkˈtəʊpəmiːn|
[f. octopus + amine, the compound having been first identified in salivary extracts from an octopus.]
A weakly sympathomimetic amine, HO·C6H4·CHOH·CH2NH2, which under the action of monoamine oxidase inhibitors may accumulate in nerves in place of the closely related noradrenaline, thereby inhibiting the transmission of nerve impulses and causing vasoconstriction; 1-(3-hydroxyphenyl)-2-aminoethanol.
1948V. Erspamer in Acta Pharmacol. IV. 245 It is suggested that the parent substance of the adrenaline-like principle in the salivary extracts should be called ‘Octopamine’. 1952Nature 1 Mar. 376/1 Having identified octopamine as norsynephrine, it was obvious to expect that hydroxyoctopamine could be identified as..noradrenaline. This assumption was confirmed experimentally. 1970Passmore & Robson Compan. Med. Stud. II. xv. 32/2 Octopamine is a much weaker adrenergic receptor activator than noradrenaline and replacement by it of a portion of the noradrenaline released by nerve stimulation could result in a diminished response of the effector tissue. 1972Florkin & Bricteux-Grégoire in Florkin & Scheer Chem. Zool. VII. x. 323 Octopamine may result from the decarboxylation of p-hydroxyphenylserine.., but it is known that octopamine may also result from the oxidation of tyramine... Octopamine itself can be oxidized into..noradrenaline. |