| 释义 |
ochronosis|əʊkrəˈnəʊsɪs|
Path. [mod.L. (R. Virchow 1866, in Arch. f. path. Anat. u. Physiol. XXXVII. 218), f. Gr. ὠχρός pale yellow + νόσος disease + ] An abnormal brown pigmentation of tissue, notably cartilage, esp. when a symptom of the metabolic disorder alkaptonuria and resulting from the accumulation of polymerized homogentisic acid.
1867Half-Yearly Abstr. Med. Sci. LXV. 28 Virchow proposes to call this affection ochronosis. 1876tr. Wagner's Gen. Pathol. (ed. 6) 315 Virchow describes as ochronosis a peculiar black coloration of almost all the cartilages and ligaments of the..joints of the synovial membranes. 1906Lancet 6 Jan. 26/1 The urine of his patient.., who had the blackening of cartilages which constitutes ochronosis, was brown when passed. 1948W. A. D. Anderson Path. iv. 88 Phenol poisoning, due to absorption of phenol from surgical dressings, has been reported to cause a pigmentation similar to ochronosis. 1962C. A. Clarke Genetics for Clinician xiii. 156 Alkaptonuria... In addition to the urinary abnormality..there is pigmentation of cartilage and ligaments (ochronosis). 1970Nature 21 Nov. 770/1 Adults with alcaptonuria develop a destructive arthritis secondary to the deposition of a melanin-like pigment in their connective tissues, especially skin, tendon and cartilage (ochronosis).
Hence ochroˈnotic a [-otic].
1922Arch. Internal Med. XXIX. 737 Hanseman observed diffuse and granular ochronotic pigment in the tissues. 1961Arthritis & Rheumatism IV. 137 (heading) Studies on the pathogenesis of ochronotic arthropathy. |