| 释义 |
non-nucleoside, a. and n. Biochem. and Pharmacol.
Brit. |nɒnˈnjuːklɪə(ʊ)ˌsʌɪd|, U.S. |nɑ(n)ˈn(j)ukliəˌsaɪd|
[‹ non- prefix + nucleoside n.]
A. adj. That is not a nucleoside; spec. designating drugs that inhibit retroviral reverse transcriptase but are not nucleoside analogues, used in the treatment of HIV infection.
1987Molecular & Cellular Biochem. 77 187 The synthetic nucleoside, ribavirin..and mycophenolic acid, a non-nucleoside inhibitor of inosinate (IMP) dehydrogenase, are effective inducers of terminal differentiation of Friend virus transformed murine erythroleukemia cells. 1990Science 28 Sept. 1542/1 A number of new types of non-nucleoside compounds have recently been reported to be active against HIV in vitro. 1996AIDS 10 635 Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine. 2002Washington Post (Home ed.) 26 Feb. a2/5 Researchers here also heard about the early success of a drug specifically designed to avoid resistance problems encountered by nevirapine and efavirenz, the two existing members in its class of drugs, known as non-nucleoside reverse transcriptase inhibitors.
B. n. A non-nucleoside reverse transcriptase inhibitor.
1993Nature 18 Feb. 650/1 Therapy relying on inhibitors of reverse transcriptase by nucleosides..and by non-nucleosides like pyridinones or nevirapine may exert different selection pressures on this enzyme. 2001Antiviral Res. 52 189 Severe hepatotoxicity appears in around 10% of subjects who began triple combinations including either protease inhibitors or non-nucleosides. |