| 释义 |
metronidazole, n. Pharm.|mɛtrəʊˈnaɪdəzəʊl|
[f. meth- + -tron- (perh. f. rearrangement of nitro-) + imidazole n.]
A pale yellow crystalline imidazole derivative given orally and as a vaginal pessary in treating infections with anaerobic bacteria or protozoa (e.g. trichomoniasis); 2-(2-methyl-5-nitroimidazol-1-yl)ethanol, C3HN2(CH3)(CH2CH2OH)(NO2) .
1960Brit. Med. Jrnl. 24 Sept. 903/1 In an attempt to determine the clinical efficacy of metronidazole a trial was arranged in St. Mary's Hospital for Women, Manchester. 1965I. M. Rollo in Goodman & Gilman Pharmacol. Basis Therapeutics (ed.3) liv. 1141/1 In 1959, Cosar and Julou reported the trichomonacidal activity..of 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole... Subsequent experience..has indicated that the oral administration of the drug, now called metronidazole, will cure a high proportion of infected individuals. 1974R. M. Kirk et al. Surgery ii. 24 Symptomatic disease is treated with metronidazole..given orally. 1980Brit. Med. Jrnl. 29 Mar. 882/2 In general metronidazole seems the most useful prophylactic for anaerobic organisms. 1991Saudi Med. Jrnl. XII. 117/2 These strains..have a biochemical profile similar to that of Peptostreptococcus intermedius which is resistant to metronidazole. |