| 释义 |
McArdle, n. Path.|məˈkɑːd(ə)l|
[The name of Brian McArdle (b. 1911), British physician who identified the disease in 1951 (Clin. Stud. X. 13).]
McArdle's disease or syndrome, a rare congenital metabolic disorder in which, owing to the absence of the enzyme phosphorylase, an abnormal storage of glycogen occurs in the muscles, resulting in pain and stiffness associated with exertion, and often leading to weakness and wasting.
1957Lilienthal & Zierler in Thompson & King Biochem. Disorders in Human Disease xi. 480 McArdle's syndrome. McArdle (1951) described a myopathy attributed to a defect in muscle glycogen breakdown. 1963New England Jrnl. Med. 17 Jan. 136/2 The 2 cases presented appear to constitute a new..variety of skeletal-muscle phosphorylase deficiency..in contrast to previous cases of ‘McArdle's disease’ with symptoms beginning in childhood. 1982T. M. Devlin Textbk. Biochem. vii. 385 Also called type V glycogen storage disease, McArdle's disease is caused by an absence of muscle phosphorylase. 1984Tampa Tribune 5 Apr. 20 a/2 She describes her suffering from McArdle's Syndrome, a rare muscle disease. |