| 释义 |
‖ xanthoma Path.|zænˈθəʊmə|
Pl. xanthomas, xanthomata.
[f. Gr. ξανθός yellow + -ωµα (cf. sarcoma).]
An affection of the skin, characterized by the growth of yellowish patches or tubercles. Also, esp. in mod. use, such a patch or tubercle. Freq. with mod.L. adjs. Also attrib.
1869Jrnl. Cutaneous Med. III. 241 (heading) On xanthoma, or vitiligoidea. Ibid. 317 After entry into hospital, patches of xanthoma developed in both eyelids. 1874W. Tay tr. Hebra & Kaposi's Dis. Skin III. 345 There are two forms of the disease—1st, it occurs in the form of yellow patches—Xanthoma planum..; 2nd, in the form of tubercles—Xanthoma tuberosum. 1876Duhring Dis. Skin 410 Xanthoma is a connective-tissue new growth, characterized by the formation of yellowish, circumscribed, irregularly shaped,..non-indurated patches or tubercles. 1896N. Walker tr. Unna's Histopath. Dis. Skin 945 The xanthoma of the eyelid may gradually develop protuberances, without giving up its own peculiar histological character. 1899Allbutt's Syst. Med. VIII. 484 The chamois-leather-like patches may simulate xanthoma. Ibid. 896 The so-called ‘xanthoma cell’ is..a fragmented muscle fibre in a state of granulo-fatty degeneration. 1949R. L. & R. L. Sutton Handbk. Dis. Skin 385 Tuberous xanthomas are occasionally solitary. 1961Lancet 12 Aug. 341/2 All her plasma-lipids tended to return to normal values..and her xanthomata completely disappeared. 1968A. Rook et al. Textbk. Dermatol. II. xxxviii. 1229/1 Xanthoma disseminatum is a rare histiocytic proliferative disorder characterized by widespread cutaneous xanthomata..but usually without evidence of systemic disturbance of lipid metabolism. 1974S. L. Robbins Pathologic Basis Dis. xxx. 1410/1 These xanthomas may be widespread and occur in varied forms, such as xanthoma tuberosum.
Hence xanthomaˈtosis, a metabolic disorder marked by the accumulation of excess lipid and by the presence of multiple and wide-spread xanthoma. xanthomatous |-ˈəʊmətəs| a., pertaining to or of the nature of xanthoma.
1900Dorland Med. Dict. 764/1 Xanthomatosis. 1914Lancet 13 June 1697/1 Xanthomatous nodules in the liver. 1923Brit. Jrnl. Dermatol. XXXV. 90 Xanthomatosis is probably a process of infiltration dependent primarily upon hypercholesterolæmia. 1961[see hypercholesterolæmic adj. s.v. hyper- IV]. 1983Oxf. Textbk. Med. I. ix. 113/1 The relationship between cerebrotendinous xanthomatosis and spinal cholesterosis..is uncertain. |