| 释义 |
von Recklinghausen's disease Path.|fɒn ˈrɛklɪŋhaʊzən|
[Named after Friedrich von Recklinghausen (1833–1910), German pathologist.]
1. A familial disease in which numerous neurofibromas develop on various parts of the body, esp. the skin, the nerve trunks, and the peripheral nerves (described by von Recklinghausen in 1882). Also Recklinghausen's disease.
1899, etc. [see neurofibromatosis]. 1900H. A. Thomson Neuroma & Neuro-Fibromatosis iv. 55 There is not even a good general name for the group which will include all its members, unless we adopt that suggested by certain French authors, viz.—‘von Recklinghausen's Disease’. 1935[see neurilemoma, neurilemmoma]. 1969S. Jablonski Illustr. Dict. Eponymic Syndromes & Dis. 256/1 (caption) Recklinghausen's disease. 1976Path. Ann. XI. 371 A total of 15 schwannomas were studied ultrastructurally. Of these, two were classified as neurofibromas by light microscopy and were associated with von Recklinghausen's disease.
2. A disease in which bones are weakened by diffuse resorption and fibrous replacement of the bone substance as a result of hyperparathyroidism, leading to bowing of long bones and sometimes deformities of the chest and spine (described by von Recklinghausen in 1891); osteitis fibrosa cystica.
1910Ann. Surg. Aug. 163 Crile and Hill interpret..as multiple giant-cell sarcoma, but it seems to me that it belongs to the group of Von Recklinghausen's disease. 1949New Gould Med. Dict. 862/1 Generalized osteitis fibrosa cystica is called von Recklinghausen's disease of the bone. 1966Wright & Symmers Systemic Path. II. xxxii. 1129/1 Some forty years elapsed before it was recognised that von Recklinghausen's disease of the bones was..directly due to an excess of circulating parathyroid hormone. 1984Tighe & Davies Pathology (ed. 4) xxi. 209 These changes produce the ‘brown tumours’ of osteitis fibrosa cystica (von Recklinghausen's disease of bone) which may be misdiagnosed as giant cell tumours of bone (osteoclastoma). |