| 释义 |
Alzheimer's disease|ˈæltshaɪməz dɪˈziːz|
[f. the name of Alois Alzheimer (1864–1915), German neurologist.]
A grave disorder of the brain which manifests itself in premature senility.
1912S. C. Fuller in Jrnl. Nervous & Mental Dis. XXXIX. 440 (title) Alzheimer's Disease (senium præcox): the report of a case and review of published cases. 1930Lancet 19 July 138/2 Two cases of Alzheimer's disease... In one typical case, that of a woman aged 51, there was a gradual failure of mental power. 1952Ibid. 27 Sept. 635/1 The characteristic changes of Alzheimer's disease could be designated..disseminated paramyloidosis of the brain. 1955H. H. Merritt Textbk. Neurology vi. 417 The microscopic changes in Alzheimer's disease are somewhat similar to those which occur with senility. There is a diffuse loss of cells in all layers of the cortex, secondary gliosis, argentophile plaques (Alzheimer plaques) and neurofibrillar degeneration. |