| 释义 |
imipramine Pharm.|ɪˈmɪprəmiːn|
[Rearrangement of some elements of dimethyl-aminopropyl-iminodibenzyl, a systematic name for this compound: see -ine5.]
A tricyclic tertiary amine, C19H24N2, given orally as the hydrochloride, a white crystalline compound, in the treatment of endogenous depression.
1958Amer. Jrnl. Psychiatry CXV. 459 (heading) The treatment of depressive states with G 22355 (imipramine hydrochloride). 1960Brit. Med. Jrnl. 30 Jan. 348/2 We have..noted the development of jaundice and also hypomania in patients receiving therapeutic doses of imipramine. 1963Lancet 23 Mar. 638/2 The administration to pregnant rabbits of imipramine (‘Tofranil’) led to the development of fœtal abnormalities. 1964Hafliger & Burckhardt in M. Gordon Psychopharmacol. Agents I. iii. 77 Imipramine has no influence upon monoamine oxidase. Ibid. 89 The most frequent side effecs of imipramine..include dryness of the mouth, sweating, disturbance of accommodation, constipation, insomnia, and giddiness. 1965Nursing Times 5 Feb. 187/1 Either electro-convulsive therapy or one of the antidepressant drugs (such as imipramine—Tofranil) will probably be used. 1965J. Pollit Depression & its Treatment iv. 58 Imipramine is effective mainly in Type S classical (retarded) depressions, and in depressed patients of middle age and over. It is less valuable in atypical depression, and in sensitive or hysterical personalities the ordinary mild side effects may cause bitter complaint. 1972Brit. Med. Jrnl. 1 Apr. 45/2 These fairly substantial figures do not support the view that imipramine is liable to cause fetal abnormalities if given to pregnant women. |