| 释义 |
allopurinol Pharm.|æləʊˈpjʊərɪnɒl|
[f. allo- + purine + -ol.]
A bicyclic pyrimidine derivative which inhibits the enzyme xanthine oxidase and hence uric acid production, and is used in the treatment of gout and other conditions involving excess uric acid; 1H-pyrazolo[3,4-d]pyrimidin-4-ol, C5H4N4O.
1964Yü & Gutman in Amer. Jrnl. Med. XXXVII. 885/2 Our chief interest in testing the new drug, now designated allopurinol, was to determine its efficacy in cases of primary and secondary gout. 1966New Scientist 16 June 692/3 Allopurinol is an example of the still comparatively small group of therapeutic substances which have been developed by chemists and pharmacologists in an attempt to regulate some specific chemical reaction within the cell. 1974M. C. Gerald Pharmacol. iv. 75 Allopurinol's development was based upon adequate biochemical knowledge of gout. 1983Oxf. Textbk. Med. II. xix. 106 In the early stages of treatment [of chronic granulocytic leukaemia], and particularly if the white cell count is very high, allopurinol, 400–600 mg daily, should be given. |