| 释义 |
filicic, a. Chem.|fɪˈlɪsɪk|
Also filixic.
[ad. G. filixsäure filicic acid (E. Luck 1851, in Jahrb. f. prakt. Pharm. XXII. 130), f. L. filic-, filix fern + -ic.]
filicic acid, a mixture of phloroglucinol derivatives obtained from the rhizome of various ferns (chiefly the common male fern, Dryopteris filix-mas), and one of the anthelmintic agents in the drug Male Fern (filix mas) (the name was orig. given to the crude extract of the fern, now called filicin). Similarly ˈfilicin [a. G. filicin (E. Poulsson 1891, in Arch. f. exper. Path. & Pharm. XXIX. 9)], (a) the crude extract of anthelmintic principles obtained from male fern; (b) the therapeutically inactive lactone of filicic acid; also loosely applied to the acid itself.
1865Brande & Cox Dict. Sci., Lit. & Art (ed. 4) I. 890/1 Filicic acid, an acid obtained from fern root. 1874Flückiger & Hanbury Pharmacographia 669 The medicinal ethereal extract, of which the rhizome yields about 8 per cent., deposits a colourless, granular, crystalline substance, noticed by Peschier as early as 1826, and subsequently designated by Luck, Filicic Acid. 1892Jrnl. Chem. Soc. LXII. i. 380 The poisonous properties of fern extract are due to an amorphous substance which is the true filicic acid. The acid is readily converted into its lactone, by simply boiling its ethereal solution. The lactone is named filicin. 1941Thorpe's Dict. Appl. Chem. (ed. 4) V. 181/2 Filicin (filicic acid)..consists of three..ketone nuclei. 1958Progress in Org. Chem. IV. 120 The ultra-violet absorption spectrum of filixic acid indicates a structure in which the three phenolic nuclei are separated by a methylene group. 1959Chem. Abstr. LIII. 14324 Filicin prepd. with Ba(OH)2 showed lower toxicity for warm-blooded animals and higher toxicity for cold-blooded animals. 1963Brit. Pharm. Codex 449 Filicin is the name given to the ether-soluble product obtained in the assay of the drug [sc. Male Fern] and the extract. 1963Acta Chem. Scand. XVII. 191 Naturally occurring filixic acid, the characteristic phloroglucinol derivative from Dryopteris filix mas, has been shown to be a mixture of six homologues, which differ from each other in regard to the acyl side chains of the filicinic acid nuclei. 1968J. H. Burn Lect. Notes Pharmacol. (ed. 9) 123 Castor oil..aids the absorption of the filicic acid in the extract of male fern. |