| 释义 |
reagin Immunol.|riːˈeɪdʒɪn|
[a. G. reagin, f. reag-ieren to react + -in -ine5.]
a. The complement-fixing substance in the blood of persons with syphilis which is responsible for the positive response to the Wassermann reaction.
1911R. W. Matson tr. A. Wolff-Eisner's Clin. Immunity & Sero-Diagnosis iii. 33 To avoid errors, it is..best to use the term ‘reactive substances’ (reagins) rather than ‘antibodies’, since the latter implies a neutralization in the sense of an antitoxin. 1915J. E. R. McDonagh Biol. & Treatm. Venereal Dis. x. 71 Owing..to the fact that a positive Wassermann reaction may be obtained in conditions other than syphilitic ones, the reaction ceases to be a specific reaction. Therefore the third factor ought not to be called an antibody, since it is in no wise specific, hence it is best called reacting substance, or Reagin. 1937H. Eagle Lab. Diagnosis Syphilis i. 24 There is reason to believe that Wasserman's first theory was correct, and that the active component of syphilitic serum, so-called reagin, may well be an antibody to Spirochaeta pallida despite its reactivity with normal tissue lipoids. 1942Jrnl. Lab. & Clin. Med. XXVII. 729 It seems controversial as to whether reagin is an antibody to lipid haptens of the host..or an antibody to the spirochete. 1976A. E. Wilkinson in Catterall & Nicol Sexually Transmitted Dis. 215 Although the function of reagin is still uncertain, its level seems to be roughly related to the amount of tissue reaction by the host, rising rapidly with increasing numbers of treponemes in early syphilis and later falling as the number of organisms declines with developing immunity.
b. The antibody which is involved in allergic reactions, causing the release of histamine and similar agents when it combines with antigen in tissue and capable of producing sensitivity to the antigen when introduced into the skin of a normal individual.
1925[see atopy]. 1963Advances in Immunol. III. 181 Reagin still represents a nebulous concept to many immunologists, some doubting the legitimacy of its classification as an antibody. 1969R. S. Weiser et al. Fund. Immunol. xv. 163 The antibodies responsible for P-K type sensitivities, the so-called ‘reagins’ or P-K antibodies, have long been a mystery. 1977Nature 16 June 618/1 Allergic diseases such as hay fever, extrinsic asthma, drug hypersensitivities and some forms of urticaria are mediated by allergen-specific antibodies of the IgE class, known also as reagins.
Hence reaˈginic a., of, pertaining to, or being (a) reagin.
1931A. F. Coca Asthma & Hay Fever in Theory & Pract. I. xvii. 332 Bona fide reaginic reactions are indicative of past, present or potential sensitivities in the atopic individual. 1945Vet. Rec. LVII. 339/2 (heading) Reaginic allergy in cattle. 1975Nature 6 Feb. 475/1 In the rat, reaginic antibodies were reported and their possible significance in S[chistosoma] mansoni infection considered. 1977A. M. Denman in Holborow & Reeves Immunol. in Med. x. 295 IgE constitutes the major class of reaginic antibody but it seems likely that some IgG..antibodies also contribute. |