| 释义 |
Tay-Sachs Path.|teɪˈsæks|
The names of Warren Tay (1843–1927), British ophthalmologist, and Bernard Sachs (1858–1944), American physician and neurologist, used attrib. and absol. with reference to a fatal inherited metabolic disorder in which an enzyme deficiency causes accumulation of a ganglioside in the brain and elsewhere, resulting in idiocy and death in childhood (described by them in 1881 and 1887 respectively). [Named in Ger. by H. Higier 1901, in Neurologisches Centralblatt XX. 851.]
1907Index Medicus V. 841/1 Hereditary infantile cerebellar ataxy and the Tay-Sachs disease. 1937[see amaurotic a.]. 1974Sci. Amer. Mar. 63/2 (Advt.), A Tay-Sachs child develops normally for his first six months. Then, as excessive fatty deposits accumulate in his brain cells, he regresses... Usually before his fifth birthday, he dies. 1975Nature 8 May 101/3 Israel's best known ethnic malady is Tay-Sachs Disease, a fatal genetic disorder limited almost entirely to infants whose forebears came here from certain parts of East Europe. |