chol·er \ˈkälə(r), ˈkōl-\noun (-s) Etymology: Middle English coler, from Middle French colere, from Latin cholera bilious disease, from Greek, from cholē bile; akin to Irish Gaelic galar disease — more at gall 1. a.archaic: yellow bile b.obsolete: bile 1a 2.obsolete: biliousness 3.: irascibility : ready disposition to anger and irritation < my choler rising at the virulence of her invective — Ellery Sedgwick >