an influence for evil or misfortune that comes or seems to come in or as if in response to imprecation or as retribution

There seemed to be a curse on the family

a cause of misfortune

Extreme conscientiousness can be more of a curse than an advantage

(the curse) informal, dated menstruation

to call upon divine or supernatural power to cause harm or injury to (somebody or something); to doom or damn (somebody or something)

to use profanely insolent language against (somebody)

(often + with) to afflict (somebody) with something unwelcome

am cursed with poor eyesight

to utter curses; to swear