1. Burdened by cares
   "all ye that labour and are heavy-laden"
   - care-laden 
2. Bearing a physically heavy weight or load
   "a heavy-laden cart"
   - burdened, loaded down

See also: encumbered, troubled

• Second Epistle to the Thessalonians
• Second Epistle to Timothy
• second estate
• first-class honors degree
• first-class honours degree
• first-class mail
• first-come-first-serve
• first-degree burn
• first-generation
• first-nighter
• first-order correlation
• first-place finish
• first-rate
• first-rater
• first-string
• first-time buyer
• first-year
• firstborn
• firsthand
• firstling
• firstly
• firth
• Firth of Clyde
• Firth of Forth
• FISA