1. Full of sorrow
   - brokenhearted, heartbroken 
2. Without or almost without hope
   "too heartsick to fight back"
   - despondent

See also: heartsickness, hopeless, sorrowful

• commonwealth
• commonwealth country
• Commonwealth Day
• Commonwealth of Australia
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• Commonwealth of the Bahamas
• commotion
• commove
• communal
• communalise
• communalism
• communalist
• communalize
• communally
• commune
• communicability
• communicable
• communicable disease
• communicant
• communicate
• communicating
• communicating artery