1. Full of sorrow
   - brokenhearted, heartbroken 
2. Without or almost without hope
   "too heartsick to fight back"
   - despondent

See also: heartsickness, hopeless, sorrowful

• residentially
• residentiary
• residual
• residual clay
• residual oil
• residual soil
• residuary
• residue
• residuum
• resift
• resign
• resignation
• resignedly
• resile
• resilience
• resiliency
• resilient
• resiliently
• resin
• resinate
• resinated
• resinlike
• resinoid
• resinous
• resiny