1. Full of sorrow
   - brokenhearted, heartbroken 
2. Without or almost without hope
   "too heartsick to fight back"
   - despondent

See also: heartsickness, hopeless, sorrowful

• ladybird beetle
• ladybug
• ladyfinger
• ladyfish
• ladylike
• ladylikeness
• ladylove
• Ladyship
• laelia
• Laertes
• laetrile
• laevo-
• laevorotatary
• laevorotatory
• laevulose
• Lafayette
• Laffer
• Laffer curve
• Laffite
• Lafitte
• Lafora's disease
• lag
• Lag b'Omer
• lag bolt
• lag screw