1. Unpleasantly
   "his ignorance was painfully obvious"
   - distressingly 
2. In or as if in pain
   "she moved painfully forward"
   - sorely

See also: painful

Antonym: painlessly

• Simonise
• Simoniz
• Simonize
• simony
• simoom
• simoon
• simp
• simpatico
• simper
• simperer
• simperingly
• simple
• simple absence
• simple closed curve
• simple eye
• simple fraction
• simple fracture
• simple fruit
• simple harmonic motion
• simple interest
• simple leaf
• simple machine
• simple mastectomy
• simple microscope
• simple mindedness