1. With curses
   "muttering profanely" 
2. In an irreverent or profane manner
   "he kept wondering profanely why everything bad happened to him"

See also: profane

• hand and foot
• hand and glove
• hand ax
• hand axe
• hand blower
• hand brake
• hand calculator
• hand cheese
• hand clapping
• hand cream
• hand drill
• hand fern
• hand glass
• hand grenade
• hand in glove
• hand in hand
• hand job
• hand lotion
• hand luggage
• hand mirror
• hand mower
• hand organ
• hand over fist
• hand pump
• hand puppet