1. Regardless; a combination of irrespective and regardless sometimes used humorously

Encyclopedia: Irregardless

• updating
• updation
• Updike
• updraft
• upend
• upended
• upending
• upfield
• upfront
• upgradation
• upgrade
• upgrowth
• upheaval
• upheave
• uphill
• uphold
• upholder
• upholster
• upholsterer
• upholstery
• upholstery material
• upholstery needle
• Upjohn
• upkeep
• upland