1. Exceedingly harmful
   - deadly, pernicious, pestilent 
2. Deadly or sinister
   - baleful

See also: maleficent, noxious

• setting
• setting hen
• settle
• settle down
• settle on
• settled
• settlement
• settlement house
• settler
• settling
• settlings
• settlor
• Setubal
• setup
• Seurat
• Sevastopol
• seven
• Seven Hills of Rome
• seven iron
• seven seas
• Seven Wonders of the Ancient World
• Seven Wonders of the World
• Seven Years' War
• seven-day
• seven-membered