1. Sufficiently significant to affect the whole world
   - earthshaking, world-shaking, world-shattering

See also: important, significant

• Macronectes
• Macronectes giganteus
• macrophage
• Macropodidae
• Macropus
• Macropus agiles
• Macropus giganteus
• Macrorhamphosidae
• macroscopic
• macroscopic anatomy
• macroscopical
• macroscopically
• macrosporangium
• macrospore
• Macrothelypteris
• Macrotis
• Macrotis lagotis
• macrotus
• Macrotus californicus
• Macrotyloma
• Macrotyloma uniflorum
• Macrouridae
• macrozamia
• Macrozamia communis
• Macrozamia spiralis