1. Extremely and sharply
   - bitterly, bitingly, bitter 
2. In a shrill voice
   - shrilly

See also: piercing

• servlet
• servo
• servomechanical
• servomechanism
• servomotor
• servosystem
• Serzone
• sesame
• sesame family
• sesame oil
• sesame seed
• sesamoid
• sesamoid bone
• Sesamum
• Sesamum indicum
• sesbania
• Sesbania exaltata
• Sesbania grandiflora
• Seseli
• Sesotho
• sesqui-
• sesquicentenary
• sesquicentennial
• sesquipedalia
• sesquipedalian