1. Extremely irritating to the nerves
   - nerve-racking, stressful, trying

See also: disagreeable

• insectivorous
• insecure
• insecurely
• insecureness
• insecurity
• inseminate
• insemination
• insensate
• insensately
• insensibility
• insensible
• insensibly
• insensitive
• insensitively
• insensitiveness
• insensitivity
• insentience
• insentient
• inseparability
• inseparable
• inseparableness
• inseparably
• insert
• insertion
• insertional mutagenesis