1. Definitely not
   "the prize is by no means certain"
   - not by a long sight, not by a blame sight

Antonym: by all means

• obstacle
• obstacle course
• obstacle race
• obstetric
• obstetrical
• obstetrical delivery
• obstetrical toad
• obstetrician
• obstetrics
• obstinacy
• obstinance
• obstinate
• obstinately
• obstipate
• obstipation
• obstreperous
• obstreperously
• obstreperousness
• obstruct
• obstructed
• obstructer
• obstruction
• obstruction of justice
• obstructionism
• obstructionist