alkylate
/ˈalkɪleɪt
/verb [with object] (usually as adjective alkylating or alkylated) Chemistry
Introduce an alkyl radical into (a compound): alkylating agents...
- Chemical mutagens are classified as alkylating agents, cross-linking agents, and polycyclic aromatic hydrocarbons (PAHs).
- Two men discovered that in the presence of Lewis acids (such as aluminum chloride or ferric chloride), alkyl halides will alkylate benzenes.
- The major categories are alkylating agents, antimetabolites, plant alkaloids, anti-tumor antibiotics, and steroid hormones.
Derivatives
alkylation
- Important synthetic methodology also exists for the alkylation of enolate ions.
- These reactions occur via acylation or alkylation and are often rapid, forming stable primary amide or secondary amine bonds.
- Likewise the mustard nitrogen of chlorambucil should not be covalently joined to antibody, since it must be free to generate the toxic aziridinium ion responsible for DNA alkylation.