A colourless compound with a similar distribution and effect to spermine.
A polyamine; chemical formula: H2N(CH2)3NH(CH2)4NH2.
The present study indicates that DNA resolubilization at high concentrations of spermine and spermidine is explained by formation of small particles of condensed DNA that cannot be precipitated by centrifugation....
These specificities lead to preferential bindings through the DNA minor groove for putrescine and spermidine, whereas spermine binds by the major groove.
Maybe even higher efficiencies would have been obtained using spermine instead of spermidine.