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单词 physostigmine
释义

physostigmine

/ˌfʌɪsəʊˈstɪɡmiːn /
noun [mass noun] Chemistry
A compound which is the active ingredient of the Calabar bean and is used medicinally in eye drops on account of its anticholinesterase activity.
  • A tricyclic alkaloid; chemical formula: C15H21N3O2.
Julian was interested in medicinal plants, particularly the Calabar bean whose active principle, physostigmine, was first isolated by the German chemists Jobst and Hesse in 1864....
  • The symptoms of anticholinergic overdose may be treated with physostigmine in a dosage of 1 to 2 mg given intramuscularly or intravenously at 20-minute intervals.
  • But since physostigmine could be isolated only from the Calabar bean, the drug was not readily available.

Origin

Mid 19th century: from the modern Latin genus name Physostigma (to which the Calabar bean belongs) + -ine4.

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更新时间:2024/9/20 18:49:13