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单词 pharmacophore
释义

pharmacophore

/ˈfɑːməkəˌfɔː /
noun
A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand....
  • The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.
  • The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.
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更新时间:2024/12/23 9:35:27