单词	phagosome
释义	phagosome /ˈfaɡə(ʊ)səʊm / noun Biology A vacuole in the cytoplasm of a cell, containing a phagocytosed particle enclosed within a part of the cell membrane.The researchers engineer a BCG strain that secretes the listeriolysin protein, which punches holes in the membranes of phagosomes where M. tuberculosis is located, allowing better T cell-mediated immunity.... The process of phagocytosis continues until the bacterium is completely internalized, surrounded by membrane in the phagosome. After internalization of organisms into phagosomes, secondary lysosomes are fused to form the complete parasitophorus vacuole. Derivatives phagosomal adjective ... Failure of mycobacteria to survive in the absence of specific iron uptake system suggests the scarcity of this important nutrient in phagosomal environment 59. Electrons are transferred from cytoplasmic NADPH to oxygen on the phagosomal side of the membrane, generating the so-called reactive oxygen species, e.g., superoxide, hydrogen peroxide, hydroxyl radical, and singlet oxygen. The lack of urease C allows phagosomal acidification and provides an ideal pH environment for listeriolysin.
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