ague cake
/ˈeɪɡjuː ˌkeɪk/Now historical
noun
An enlarged spleen (or occasionally liver) in a person suffering from malaria; (also) the condition of enlargement of the spleen, especially in malaria.
Origin
Late 16th century; earliest use found in William Langham (fl. 1597), doctor and herbalist. From ague + cake.