Early 17th century; earliest use found in Robert Burton (1577–1640), writer. From post-classical Latin elleborismus purgative made from hellebore or its etymon ancient Greek ἐλλεβορισμός, ἑλλεβορισμός treatment with hellebore from ἐλλεβορίζειν, ἑλλεβορίζειν + -ισμός.