单词	frameshift mutation
释义	frameshift mutation /ˈfreɪmʃɪft mjuˌteɪʃ(ə)n / noun Genetics A mutation caused by the addition or deletion of a base pair or base pairs in the DNA of a gene resulting in the translation of the genetic code in an unnatural reading frame from the position of the mutation to the end of the gene.We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene.... This frameshift mutation (deletion at positions 1151-1160) could be merely drifting to high frequency due to weak functional constraint. In ORF 2 there is a deletion of 11 nucleotides that causes a frameshift mutation and a premature stop codon; an additional 1 bp insertion is located further downstream.
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