Substantially reduce the population of (an area):the disease could depopulate a town the size of Bournemouth...
The valleys have not lost their character but agricultural and industrial changes have depopulated some areas and opened others to an influx of lowlanders seeking holiday and retirement homes.
For much of the period 1920-1980, large parts of the northern coastal area were effectively depopulated.
About 4,000 villages have been burnt and razed to the ground in an attempt to depopulate the area.
Origin
Mid 16th century (in the sense 'ravage, lay waste'): from Latin depopulat- 'ravaged', from the verb depopulari, from de- 'completely' + populari 'lay waste' (from populus 'people').