单词	degranulate
释义	degranulate /diːˈɡranjʊleɪt / verb [no object] Physiology (Of a cell) lose or release granules of a substance, typically as part of an immune reaction: the eosinophils degranulate, releasing the toxic contents of the granules... When mast cells degranulate they release tryptase, in addition to histamine and prostaglandins. We found corroborative evidence that neutrophils are stimulated to degranulate and produce reactive oxidants in the airways of children with Cystic Fibrosis. IL - 8 also activates neutrophils to degranulate and cause tissue damage. Derivatives degranulation noun ... Mast cell degranulation releases vasoactive substances, including histamine, which sustain the reaction by depositing additional immune complexes. The ‘itch-scratch’ cycle induces mast cell degranulation and cytokines that may respond to antihistamines. The data from guinea pigs were confirmed in the human system; IL - 8-activated neutrophils stimulated degranulation, and this was inhibited by elastase inhibitors.
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