Definition of tachyphylaxis in English:
tachyphylaxis
nounˌtakɪfɪˈlaksɪsˌtakəfiˈlaksəs
mass nounMedicine Rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system.
Example sentencesExamples
- Topical steroids should be applied no more than twice a day; more frequent use provides no advantage and may induce tachyphylaxis.
- Trebling doses of histamine diphosphate were chosen instead of the usual doubling dose because of the half-life of lidocaine, the number of challenges, and the need to minimize possible tachyphylaxis of the histamine effect.
- Giving methotrexate concurrently, however, suppressed tachyphylaxis, probably by preventing the production of human antichimeric antibodies.
- The efficacy of calcipotriene is comparable to mid-potency topical corticosteroids; however, it does not cause skin atrophy or tachyphylaxis.
- This spirometric improvement was maintained throughout the 13-week period without any evidence of tachyphylaxis.