Definition of sickle-cell anaemia in English:

sickle-cell anaemia

(also sickle-cell disease)

nounˌsɪkəlsɛl əˈniːmɪə

mass noun

A severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent.
Example sentencesExamples
- Already the genes for many diseases, from sickle-cell anemia to heart disease, have been pinpointed, though genetic means of treating them are still in their infancy.
- One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease.
- Thousands of children with thalassemia, sickle-cell anemia, Fanconi anemia, various leukemias, and certain other circulatory conditions could benefit from the same innovative battery of procedures.
- An important breakthrough was the concept of molecular disease, introduced in the late 1940s with Linus Pauling's elucidation of the underlying basis of sickle-cell anemia.
- A Blackpool group has organised an Afro-Caribbean night in the town to raise awareness of the hereditary blood disorder, sickle-cell anaemia.
- In the study's earlier years, the first 12 children with sickle-cell disease received a bone marrow transplant plus busulfan and cyclophosphamide, two drugs known to facilitate transplants.
- His work focused on the antigen-antibody reaction and the structure of proteins and, in 1949, Pauling's team discovered the molecular basis of sickle-cell anemia.
- Genetic changes in the hemoglobin molecule that affect the shape of the red blood cell and the oxygen carrying capacity of the cell result in the inheritable diseases of sickle-cell anemia and beta-thalassemia.
- The blood condition sickle-cell anaemia is most common in people from Africa, the Caribbean, the eastern Mediterranean, the Middle East and Asia.
- One out of four African Americans is born with alpha-thalassemia; therefore, at birth, one-fourth of African Americans with sickle-cell disease have this ameliorating condition.
- If an individual inherits the mutation in both genes they will have sickle-cell disease.
- In the simplest cases, such as sickle-cell anemia, diseases can be linked to a single gene.
- The homozygous sickle-cell condition is responsible for the deadly effects of sickle-cell anemia, whereas the heterozygous condition is usually asymptomatic.
- People with two copies of a form of a particular gene develop sickle-cell anemia, but people with one copy of that form show high resistance to malaria.
- Humans are polymorphic for skin colour, body stature, sickle-cell anaemia, blood groups and the epicanthic eye-fold.
- My dad won the monthly National Science Prize when he designed a better cure for sickle-cell anemia.
- She talks about beauty basics, as well as major concerns affecting darker skins, such as the effects of sickle-cell disease, scars and keloids.
- It says the school's use of race and ethnicity for research was similar to a medical school's use of Jewish patients to study Tay-Sachs disease, or Blacks to study sickle-cell anemia.
- Infection can produce severe anaemia and an aplastic crisis in people with sickle-cell anaemia or other abnormalities of haemoglobin.
- In sickle-cell disease, the haemoglobin is abnormal and this causes a change in the shape of the red blood cells.

单词	sickle-cell anaemia
释义	Definition of sickle-cell anaemia in English: sickle-cell anaemia (also sickle-cell disease) nounˌsɪkəlsɛl əˈniːmɪə mass noun A severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent. Example sentencesExamples Already the genes for many diseases, from sickle-cell anemia to heart disease, have been pinpointed, though genetic means of treating them are still in their infancy. One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease. Thousands of children with thalassemia, sickle-cell anemia, Fanconi anemia, various leukemias, and certain other circulatory conditions could benefit from the same innovative battery of procedures. An important breakthrough was the concept of molecular disease, introduced in the late 1940s with Linus Pauling's elucidation of the underlying basis of sickle-cell anemia. A Blackpool group has organised an Afro-Caribbean night in the town to raise awareness of the hereditary blood disorder, sickle-cell anaemia. In the study's earlier years, the first 12 children with sickle-cell disease received a bone marrow transplant plus busulfan and cyclophosphamide, two drugs known to facilitate transplants. His work focused on the antigen-antibody reaction and the structure of proteins and, in 1949, Pauling's team discovered the molecular basis of sickle-cell anemia. Genetic changes in the hemoglobin molecule that affect the shape of the red blood cell and the oxygen carrying capacity of the cell result in the inheritable diseases of sickle-cell anemia and beta-thalassemia. The blood condition sickle-cell anaemia is most common in people from Africa, the Caribbean, the eastern Mediterranean, the Middle East and Asia. One out of four African Americans is born with alpha-thalassemia; therefore, at birth, one-fourth of African Americans with sickle-cell disease have this ameliorating condition. If an individual inherits the mutation in both genes they will have sickle-cell disease. In the simplest cases, such as sickle-cell anemia, diseases can be linked to a single gene. The homozygous sickle-cell condition is responsible for the deadly effects of sickle-cell anemia, whereas the heterozygous condition is usually asymptomatic. People with two copies of a form of a particular gene develop sickle-cell anemia, but people with one copy of that form show high resistance to malaria. Humans are polymorphic for skin colour, body stature, sickle-cell anaemia, blood groups and the epicanthic eye-fold. My dad won the monthly National Science Prize when he designed a better cure for sickle-cell anemia. She talks about beauty basics, as well as major concerns affecting darker skins, such as the effects of sickle-cell disease, scars and keloids. It says the school's use of race and ethnicity for research was similar to a medical school's use of Jewish patients to study Tay-Sachs disease, or Blacks to study sickle-cell anemia. Infection can produce severe anaemia and an aplastic crisis in people with sickle-cell anaemia or other abnormalities of haemoglobin. In sickle-cell disease, the haemoglobin is abnormal and this causes a change in the shape of the red blood cells.
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