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Definition of Santa Cruz in English: Santa Cruzproper nounkruθkruskruːz 1A city in the central region of Bolivia; population 1,561,061 (2009). 2A port and the chief city of the island of Tenerife, in the Canary Islands; population 221,956 (2008). Full name Santa Cruz de Tenerife.
Definition of Santa Cruz in US English: Santa Cruzproper noun 1A city in central Bolivia; population 1,561,061 (2009). 2A port and the chief city of the island of Tenerife, in the Canary Islands; population 192,000. Full name Santa Cruz de Tenerife. 3A city in west central California, on Monterey Bay; population 56,124 (est. 2008).
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