A chapel in the Vatican, built in the late 15th century by Pope Sixtus IV, containing a painted ceiling and fresco of the Last Judgement by Michelangelo and also frescoes by Botticelli.
Definition of Sistine Chapel in US English:
Sistine Chapel
proper nounˈsiˌstēn ˈCHapəl
A chapel in the Vatican, built in the late 15th century by Pope Sixtus IV, containing a painted ceiling and fresco of the Last Judgment by Michelangelo and also frescoes by Botticelli.