Definition of provirus in English:
provirus
noun prəʊˈvʌɪrəsprōˈvīrəs
Microbiology The genetic material of a virus as incorporated into, and able to replicate with, the genome of a host cell.
Example sentencesExamples
- The FeLV-induced tumors are thought to be caused, at least in part, by somatically acquired insertional mutagenesis in which the integrated provirus may activate a proto-oncogene or disrupt a tumor suppressor gene.
- Once integrated with the host's genetic material, the DNA version of the retroviral RNA is called a provirus.
- HERV-W proviruses probably entered the genome of primates before the split between Old World and New World monkeys.
- Both retrovirus-like organization and expression are typical of the functional gypsy proviruses that have inserted recently into the euchromatic DNA of some strains.
- Recombination requires the simultaneous infection of a cell with two different proviruses, allowing the encapsulation of one RNA transcript from each provirus into a heterozygous virion.
Derivatives
adjective
Microbiology It is generally admitted that these Human Endogenous RetroViruses derive originally from rare events of germ-line infections by exogenous retroviruses leading to proviral DNA integration.
Example sentencesExamples
- Endogenous retroviruses are the proviral form of exogenous retroviruses that have become integrated into the germ line of the host.
- Identification of clonal proviral insertions by oncogenic retroviruses has led to the isolation of novel tumor-associated genes.
- To identify expressed sequences, 16 kb of genomic DNA flanking the proviral integration site was sequenced and compared to genetic databases.
- Emery et al 40 found that, at autopsy, the presence of HHV - 6 DNA was associated with significant increases in HIV - 1 proviral DNA.