Definition of lamellipodium in English:
lamellipodium
nounPlural lamellipodia ləˌmɛlɪˈpəʊdɪəmləˌmeləˈpōdēəm
Zoology A flattened extension of a cell, by which it moves over or adheres to a surface.
Example sentencesExamples
- Many models are based on the fact that the actin polymerization is a major contributor to the protrusive force, which leads to the extension of the lamellipodia of crawling cells on a hard substrate.
- In cells without a lamellipodium, the lamella reached all the way to the leading edge and the pattern of turnover did not deviate from its randomness, even in phases of pronounced protrusion.
- Polymerization is thought to generate protrusive forces that push forth a lamellipodium and begin the cell motility cycle.
- In these motile cells, lamellipodia of various shape are continually extended in different directions.
- More specifically, an increase in thermal fluctuations of actin filaments in the softer cells and the lamellipodium can expedite the intercalation of G-actin that leads to the enhanced protrusion.
Derivatives
adjective
Zoology Actin, the major component of the lamellipodial cytoskeleton, exists in monomeric (G-actin) and rod-like polymerized filament (F-actin) forms.
Example sentencesExamples
- Kymographic analysis of EGF-stimulated lamellipodial dynamics revealed that the temporal stability of lamellipodial protrusions similarly increased with fibronectin concentration.
- Third, as far as the diffusion-limited growth is concerned, our estimates were made for the steadily protruding lamellipodial leading edge.
- Interestingly, that the stability of lamellipodial protrusion events also increases upon addition of EGF indirectly supports the idea that EGF actually increases adhesion at the front of cells.
- Another possible role of relatively rigid actin bundles embedded into the lamellipodial actin sheet is to strengthen the lamellipodium against buckling, by analogy with engineered macroscopic structures.
Origin
1970s: from lamella, on the pattern of pseudopodium.