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单词 agonist
释义

Definition of agonist in English:

agonist

noun ˈaɡənɪstˈæɡənəst
  • 1Biochemistry
    A substance which initiates a physiological response when combined with a receptor.

    Compare with antagonist
    Example sentencesExamples
    • For example, the highly potent opioid receptor agonist etorphine is not a medically useful drug because it can only be used a few times before the body becomes desensitized to the drug.
    • Medications that can reduce androgen levels include estrogen, gonadotropin-releasing hormone agonists, and glucocorticoids.
    • These observations provide support for the model that glucose and structurally related sugars are agonists of the Gpr1 receptor.
    • They may mimic naturally occurring steroids, act as hormone receptor agonists or antagonists or alter the enzymes responsible for hormone synthesis and degradation.
    • Opioid receptor agonists act at sites that are distributed throughout this circuit to produce analgesia.
  • 2Anatomy
    A muscle whose contraction moves a part of the body directly.

    as modifier there is a failure to select the right agonist muscles
    Compare with antagonist
    Example sentencesExamples
    • It's a matter of muscle aesthetics: The upper arm looks best when both its opposing muscle groups, the agonists and antagonists - that's bis and tris to you - carry a complementary amount of muscle.
    • In addition, we believe that the agonist / antagonist muscle ratios are important values when considering how the scapula provides stability, mobility, and symptom-free function.
    • Alternate between agonist and antagonist muscle groups (e.g… quadriceps and hamstrings), and alternate sides.
    • Muscles may act as agonists, antagonists, synergics and fixators.
    • The agonist and antagonist muscles work in concert to create muscular balance in the human body.
  • 3

    another term for protagonist
    Example sentencesExamples
    • To every agonist, there is an antagonist.
    • But now, replying to Harapha’s taunts with a startling invitation to combat, Samson is confident as the agonist was never before depicted.

Derivatives

  • agonism

  • noun
    • An agonist is described as a drug that binds to and activates receptors; the possibility of spontaneous receptor activity and therefore of inverse agonism is not mentioned.
      Example sentencesExamples
      • Rather, all known abused drugs affect a limited number of neurotransmitters by agonism or antagonism of a specific receptor site.
      • Pharmacologically, it is characterized by the constitutive activity of the ligand-free receptor, and by the inverse, partial, and full agonism due to the bound ligand.
      • Studies have clearly demonstrated that key therapies in the acute attack of migraine share the common pharmacologic activity of serotonin receptor agonism.

Origin

Early 20th century: from Greek agōnistēs 'contestant' (a sense reflected in English in the early 17th century), from agōn 'contest'.

Rhymes

antagonist, protagonist
 
 

Definition of agonist in US English:

agonist

nounˈæɡənəstˈaɡənəst
  • 1Biochemistry
    A substance which initiates a physiological response when combined with a receptor.

    Compare with antagonist
    Example sentencesExamples
    • These observations provide support for the model that glucose and structurally related sugars are agonists of the Gpr1 receptor.
    • For example, the highly potent opioid receptor agonist etorphine is not a medically useful drug because it can only be used a few times before the body becomes desensitized to the drug.
    • Opioid receptor agonists act at sites that are distributed throughout this circuit to produce analgesia.
    • Medications that can reduce androgen levels include estrogen, gonadotropin-releasing hormone agonists, and glucocorticoids.
    • They may mimic naturally occurring steroids, act as hormone receptor agonists or antagonists or alter the enzymes responsible for hormone synthesis and degradation.
  • 2Anatomy
    A muscle whose contraction moves a part of the body directly.

    as modifier there is a failure to select the right agonist muscles
    Often contrasted with antagonist
    Example sentencesExamples
    • It's a matter of muscle aesthetics: The upper arm looks best when both its opposing muscle groups, the agonists and antagonists - that's bis and tris to you - carry a complementary amount of muscle.
    • Muscles may act as agonists, antagonists, synergics and fixators.
    • Alternate between agonist and antagonist muscle groups (e.g… quadriceps and hamstrings), and alternate sides.
    • In addition, we believe that the agonist / antagonist muscle ratios are important values when considering how the scapula provides stability, mobility, and symptom-free function.
    • The agonist and antagonist muscles work in concert to create muscular balance in the human body.
  • 3

    another term for protagonist
    Example sentencesExamples
    • But now, replying to Harapha’s taunts with a startling invitation to combat, Samson is confident as the agonist was never before depicted.
    • To every agonist, there is an antagonist.

Origin

Early 20th century: from Greek agōnistēs ‘contestant’ (a sense reflected in English in the early 17th century), from agōn ‘contest’.

 
 
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更新时间:2024/11/11 10:09:14