The treatment of a disease with a single drug.
 Example sentencesExamples
-  It is indicated for use as monotherapy or in combination therapy with metformin, a sulfonylurea, or insulin in the treatment of type 2 diabetes.
 -  Both the systematic review and meta-analyses confirmed the superiority of combination therapy to inhaled corticosteroids monotherapy.
 -  Further studies are needed to determine nortriptyline's efficacy as monotherapy in the treatment of diabetic neuropathy.
 -  Dropout rates were similar for monotherapy and double therapy but significantly higher in trials containing protease inhibitors.
 -  As a group, these studies imply that combination treatment for most patients in hospital for mania represents a substantial acute advantage in treatment over monotherapy.