Definition of mitogen in English:
mitogen
noun ˈmʌɪtədʒ(ə)nˈmīdəjən
Physiology A substance that induces or stimulates mitosis.
Example sentencesExamples
- In vitro tests of immune function in avian wildlife include proliferation of lymphocytes in response to various mitogens and phagocytosis of fluorescent particles by monocytes.
- Cells from each individual were tested at 3 different concentrations of the mitogens for optimum stimulation.
- The technique of three-color flow cytometry was used to generate precise estimates of cytokine responses to cells collected from the blood, cultured and stimulated with a mitogen.
- Platelet-derived growth factor is a major polypeptide growth factor found in human serum, platelets and fibroblasts and is a potent mitogen for cells of mesenchymal origin.
- Pokeweed mitogen stimulates both T and B cells.
Derivatives
adjective
Physiology When associated with vesicles of dipalmitoylphosphatidylcholine, surfactant protein C inhibited the mitogenic effect of lipopolysaccharide to a macrophage cell line.
Example sentencesExamples
- In addition, muscarinic receptor stimulation augmented the mitogenic responses of human airway smooth muscle cells to epidermal growth factor.
- However, the patients despite their symptoms were all living independently and had normal proliferative responses to mitogenic stimulus and to purified protein derivative.
- Mast cells produce basic fibroblast growth factor, which is a potent mitogenic factor for proliferation of smooth muscle cells, myofibroblasts, and fibroblasts.
- Endothelin - 1 has been implicated in pulmonary hypertension because of its dual vasoconstrictor and mitogenic actions.
Origin
1960s: from mitosis + -gen.