Definition of phosphodiester bond in English:
phosphodiester bond
nounˌfɒsfə(ʊ)dʌɪˈɛstəˌfäsfōdīˈestər ˌbänd
Biochemistry A chemical bond of the kind joining successive sugar molecules in a polynucleotide.
Example sentencesExamples
- DNA ligase and RNA ligase from the bacteriophage T4 catalyze the formation of the phosphodiester bond between two molecules of nucleic acid.
- Topological problems related to DNA metabolism are solved by a class of enzymes, named DNA topoisomerases, able transiently to break and reseal phosphodiester bonds via the formation of a covalent DNA-protein intermediate.
- The alteration in size on cleavage of the phosphodiester bond at the 8-oxoguanine is detected by conventional gel electrophoresis and visualization of the P-labelled fragments.
- Certain glycosylases also have abasic lyase activity, cleaving the phosphodiester bond adjacent to the abasic deoxyribose residue.
- Ribozymes are molecules of ribonucleic acid that catalyze reactions on the phosphodiester bond of other RNAs.