Definition of phosphodiesterase in English:
phosphodiesterase
noun ˌfɒsfə(ʊ)dʌɪˈɛstəreɪzˌfäsfōdīˈestərās
mass nounBiochemistry An enzyme which breaks a phosphodiester bond in an oligonucleotide.
Example sentencesExamples
- Calf spleen phosphodiesterase, snake venom phosphodiesterase and alkaline phosphatase were from Roche Molecular Biochemicals (Meylan, France).
- One technique involves using drugs, such as a growth hormone, to activate a molecule known as ERK5, which suppresses the enzyme phosphodiesterase.
- Cilostazol blocks the activity of the enzyme phosphodiesterase which induces platelet aggregation and prevents the degradation of cyclic adenosine monophosphate (cAMP).
- In isolated cilia and in intact olfactory receptor neurons, studies have shown basal activities of both adenylate cyclase and cAMP phosphodiesterase.
- Its mechanism of action is thought to involve inhibition of cyclic adenosine monophosphate phosphodiesterase and enhancement of the effect of prostaglandin I2.