A compound present (in the form of highly carcinogenic esters) in croton oil.
A tetracyclic alcohol; chemical formula: C₂₀H₂₈O₆
Example sentencesExamples
- This is in striking contrast to phorbol esters, which mimic G q pathway-produced DAG and cause strongly hyperactive locomotion within 1-2 hr of omnidirectional contact.
- Twenty-four hours after transfection, cells were stimulated with ionomycin, phorbol 12-myristate 13-acetate, and calcium chloride.
- Various studies on the active principles of the manchineel tree have shown tigliane phorbol esters to be the likely cause of the severe reactions.
- When the phorbol ester TPA is added to MCF - 7 cells, a dramatic increase in the invasiveness and the metastatic potential of these cells occurs.
- Neutrophils stimulated to respiratory burst by phorbol myristate acetate activate IQ, and inhibitor studies have identified myeloperoxidase as the enzyme responsible.