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Definition of Philadelphia chromosome in English: Philadelphia chromosomenoun Genetics An abnormal small chromosome sometimes found in the leucocytes of leukaemia patients. Example sentencesExamples - CML is caused by the errant swapping of genetic material in bone marrow stem cells that produces an abnormality called the Philadelphia chromosome.
- The classic example of a genetic mutation, and the first identified in the study of human malignancy, is the Philadelphia chromosome, characteristic of chronic myelocytic leukemia.
- CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome.
- The malignant transformation results from a reciprocal translocation between chromosomes 9 and 22, producing a short chromosome known as the Philadelphia chromosome.
- A 27-year-old man had a known history of chronic myeloid leukemia with positive Philadelphia chromosome.
Definition of Philadelphia chromosome in US English: Philadelphia chromosomenoun Genetics An abnormal small chromosome sometimes found in the leukocytes of leukemia patients. Example sentencesExamples - CML is caused by the errant swapping of genetic material in bone marrow stem cells that produces an abnormality called the Philadelphia chromosome.
- The classic example of a genetic mutation, and the first identified in the study of human malignancy, is the Philadelphia chromosome, characteristic of chronic myelocytic leukemia.
- A 27-year-old man had a known history of chronic myeloid leukemia with positive Philadelphia chromosome.
- The malignant transformation results from a reciprocal translocation between chromosomes 9 and 22, producing a short chromosome known as the Philadelphia chromosome.
- CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome.
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