Definition of nucleosome in English:
nucleosome
noun ˈnjuːklɪə(ʊ)səʊmˈn(y)o͞oklēəˌsōm
Biology A structural unit of a eukaryotic chromosome, consisting of a length of DNA coiled around a core of histones.
Example sentencesExamples
- The packaging of DNA with histones into nucleosomes and higher-order chromatin structures has profound effects on transcription initiation.
- Histones form the core of the nucleosome around which DNA is wrapped.
- DNA replication, like other DNA-dependent processes, must contend with the organization of DNA into nucleosomes and higher-order chromatin structures.
- Histone proteins are essential components of nucleosomes in eukaryotic chromosomes.
- On a molecular level, silenced chromatin consists of specialized heterochromatin proteins and of nucleosomes carrying deacetylated histones.
Derivatives
adjective
Biology Chromatin is a complex molecular structure composed of nucleosomal repeats in which 147 bp of DNA are wrapped around two copies of the four core histones, H2A, H2B, H3, and H4.
Example sentencesExamples
- Many of these changes are larger in scale than suggested from previous studies and involve a number of DNA-mediated events, including a preference for the removal of a complete turn of nucleosomal DNA.
- The failure to recover mutations in genes encoding nucleosomal histones in this screen may be due to the presence of numerous copies of the histone gene cluster in flies.
- Histones are small basic proteins encoded by a multigene family and are responsible for the nucleosomal organization of chromatin in eukaryotes.
- In wild-type cells, the repressed state spreads unidirectionally through nucleosomal chromatin.