| Acronym | Definition |
|---|
| HPO➣High Performance Organization |
| HPO➣Hospital Police Officer (California) |
| HPO➣Hyperparameter Optimization (machine learning) |
| HPO➣High Profile Object |
| HPO➣Hamilton Philharmonic Orchestra (Ontario, Canada) |
| HPO➣Hungarian Patent Office |
| HPO➣Head Post Office |
| HPO➣High Performance Option |
| HPO➣Homeowner Protection Office (Canada) |
| HPO➣Hypothalamic-Pituitary-Ovary (biology) |
| HPO➣Highway Post Office |
| HPO➣High Priority Occupation (Pennsylvania) |
| HPO➣Health Promotion Officer |
| HPO➣High Purity Oxygen |
| HPO➣Hurricane Protection Office (USACE) |
| HPO➣Home Port |
| HPO➣Heavy Pyrolysis Oil (Chevron Phillips Chemical) |
| HPO➣High Power Objective (microscope lens) |
| HPO➣Hosted Payload Opportunities (Geostationary Earth Orbit; US NASA) |
| HPO➣Horizontal Parallax Only (electronic holography) |
| HPO➣Hitachi Philharmonic Orchestra (est. 1995; Japan) |
| HPO➣Helix-Profile Optimization |
| HPO➣Human Phenotype Ontology |
| HPO➣Hoechst Aktiengesellschaft & Co. Procurement Olefin KG |
| HPO➣Hypertrophic Pulmonary Osteopathy (pathology) |
| HPO➣Hourly Postflight Inspection |
| HPO➣Honours Pathway Option (Australia) |
| HPO➣High Power Operation |
| HPO➣Human Powered Ornithopter Project (University of Toronto; Canada) |
| HPO➣Houston Premium Outlets |